Tuesday, February 12, 2013

nrdc: President Obama pledged to address climate change, saying...






nrdc:

President Obama pledged to address climate change, saying that ?failure to do so would betray our children and future generations.?? Show him that you care too and sign up - www.nrdc.org/ForwardonClimate
We are gathering on 2/17 in Washington DC for the largest climate rally in U.S. history to tell President Obama that we can?t afford to wait any longer for solutions to climate change!

nrdc:

President Obama pledged to address climate change, saying that ?failure to do so would betray our children and future generations.?? Show him that you care too and sign up - www.nrdc.org/ForwardonClimate

We are gathering on 2/17 in Washington DC for the largest climate rally in U.S. history to tell President Obama that we can?t afford to wait any longer for solutions to climate change!

Source: http://oldparasitesingle.tumblr.com/post/42875114537

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New details on molecular machinery of cancer

Feb. 11, 2013 ? Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

"The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer," says chemist Jay Groves, one of the leaders of this research. "Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we've determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand."

Groves, who holds joint appointments with Berkeley Lab's Physical Biosciences Division and UC Berkeley's Chemistry Department, and is also a Howard Hughes Medical Institute (HHMI) investigator is one of two corresponding authors of a paper in the journal Cell that describes this research. The paper is titled "Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor." The other corresponding author is John Kuriyan, who also holds joint appointments with Berkeley Lab, UC Berkeley and HHMI.

In high school biology classes we learn that genes contain coded instructions that are translated into the assembly of specific proteins. Many proteins, however, must be activated by post-translational processes such as autophosphorylation, the addition of phosphate. Protein activation can impact many important cellular processes including proliferation, differentiation and migration. Cancer is essentially a case of these cellular functions gone wild, often the result of problems with the EGFR. However, despite its well-established links to cancer, EGFR activation has only been partially understood.

"As a member of the large class of cell surface receptors known as receptor tyrosine kinases, EGFR features a ligand-binding domain on its extracellular side and a kinase domain on its intracellular side," Groves says. "The text-book explanation for EGFR activation is that the binding of EGFR's ligand, EGF, to its extracellular side induces dimerization of the receptor, which in turn brings together the kinase domains on the intracellular sides of the dimer, allowing them to phosphorylate one another."

Groves says while the picture is accurate, it is an oversimplification of the mechanics behind the process because isolated intracellular kinase domains in solution can be active on their own at relatively low concentration without EGF ligand-induced dimerization. Dimerization is the combining of two identical molecules into a single compound molecule.

Measuring autophosphorylation as a function of EGFR surface density in cells, Groves, Kuriyan and their colleagues found that structural coupling between the EGFR transmembrane helix and extracellular juxtamembrane modules in addition to EGF ligand-engagement is required for EGFR activation. This structural coupling permits dimerization to take place in the presence of the EGF ligand.

"The un-ligated EGFR sits in a structural configuration that prevents the intracellular kinase domains from being able to reach each other," Groves says. "When the EGF ligand binds, this restraint is removed, dimerization occurs, and one kinase phosphorylates the other."

The inclusion by Groves and his colleagues of time-resolved fluorescence spectroscopy on living cells is another new advance in bringing a quantitative approach to the biological sciences. By combining picosecond light pulses from two different colors of lasers into a single beam, then genetically modifying EGFRs to carry either a red or green fluorescent protein, the researchers were able to monitor in real time how EGFRs move and assemble into dimers during activation by the EGF ligands.

"Focusing on the cell membrane and monitoring each fluorescent photon emitted, then determining both its color and precise time of arrival at the detector, allows unambiguous assignment of which photon was triggered by which color light pulse," Groves says. "All of this can be done in real time and in living cells."

With the mechanics behind the activation of EGFR now fully explained, Groves and his colleagues are now applying their quantitative biology techniques to another group of receptor tyrosine kinases, the Eph receptors, as well as T cell receptors that are so important to the immune system.

"Our broader goal with these quantitative biology techniques is to transform biology into a hard physical science," Groves says. "The idea is to move from simply describing a collage of observations to being able to understand how biological systems work based on fundamental physics."

In addition to Groves and Kuriyan, other authors of this Cell paper were Nicholas Endres, Rahul Das, Adam Smith, Anton Arkhipov, Erika Kovacs, Yongjian Huang, Jeffrey Pelton, Yibing Shan, David Shaw and David Wemmer.

This research was primarily support by a grant from the National Cancer Institute.

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Story Source:

The above story is reprinted from materials provided by DOE/Lawrence Berkeley National Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Nicholas?F. Endres, Rahul Das, Adam?W. Smith, Anton Arkhipov, Erika Kovacs, Yongjian Huang, Jeffrey?G. Pelton, Yibing Shan, David?E. Shaw, David?E. Wemmer, Jay?T. Groves, John Kuriyan. Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor. Cell, 2013; 152 (3): 543 DOI: 10.1016/j.cell.2012.12.032

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/GGEVjxy0KLI/130211150753.htm

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Monday, February 11, 2013

Sonos update bringing favorites improvements, new widget for Android app

Android Central

Sonos is rolling out an update to both its hardware setups and mobile apps to enable new features today. The first part of the update will come to the Sonos base station itself, and will improve the handling of favorites. Users will now be able to add tracks, albums and radio stations to favorites no matter the source. The new favorites can now be accessed from any Sonos Controller in the music menu as well.

An update for the Android (and iOS) Sonos Controller app is on the way to take advantage of the new features also. The Android version will receive a new widget that lets users control tracks and playback without launching the app itself, as well as show album art and metadata. The app will also receive universal search available from anywhere in the interface.

Both the system and app updates are expected to start rolling out tomorrow, so be on the lookout if you're a Sonos user.

Source: Sonos



Source: http://feedproxy.google.com/~r/androidcentral/~3/2aBNshw7xPg/story01.htm

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Market Snapshot: Stocks dragged by energy, consumer sectors

By Wallace Witkowski and Polya Lesova, MarketWatch

SAN FRANCISCO (MarketWatch) ? U.S. stocks finished slightly lower Monday on the lightest volume trading day of 2013, as energy and retail shares underperformed and investors reassessed a rally that?s lifted benchmark indexes 6% this year.

Week ahead: State of the Union, G20

President Obama will give his State of the Union address on Tuesday, and later in the week, G20 leaders convene in Moscow.

The Dow Jones Industrial Average? /quotes/zigman/627449 DJIA -0.16% ?never rose above its Friday close and ended down 21.73 points, or 0.2%, to finish at 13,971.24, with 16 of its 30 components ending down. The index traded within a narrow 53-point range throughout the session.

On the Dow, shares of Home Depot Inc. /quotes/zigman/229488/quotes/nls/hd HD -0.94% ?and UnitedHealth Group Inc. /quotes/zigman/258846/quotes/nls/unh UNH -1.07% ?led the decline, falling about 1%. Shares of blue-chips Microsoft Corp. /quotes/zigman/20493/quotes/nls/msft MSFT +1.13% ?and Pfizer Inc. /quotes/zigman/238207/quotes/nls/pfe PFE +0.97% ?gained about 1%.

The S&P 500 Index /quotes/zigman/3870025 SPX -0.06% ?slipped 0.92 point, or less than 0.1%, to close at 1,517.01, with 7 out of its 10 major sectors trading lower. The benchmark rose 0.3% last week, gaining for a sixth consecutive week.

Energy stocks led the decline even as crude futures traded higher Monday and refiners held onto recent gains. Read more on energy stocks.

The technology-heavy Nasdaq Composite index /quotes/zigman/12633936 COMP -0.06% ?fell 1.87 points, or less than 0.1%, to close at 3,192.

Trading volume was at its lowest volume of the year, bumping Friday?s low volume for that honor. Volume of NYSE-listed shares was 2.6 billion. For Nasdaq-listed shares, it was 1.54 billion. For the year to date, average daily volume is 3.59 billion for NYSE-listed shares, and 1.9 billion for Nasdaq-listed shares, according to Barclays.

Declining stocks outnumbered gainers by about 16 to 13 on the NYSE, and slightly outnumbered them on the Nasdaq.

?Largely absent any news, I?d say markets are working off an overbought phase and taking a pause,? said Mark Luschini, chief investment strategist at Janney Montgomery Scott.

Stocks have been trading near five-year highs, raising the possibility the market might be able to break out of its long period of lackluster performance, or what?s known as a secular bear market. Read: Is Bull Sprint Becoming a Marathon? at WSJ.com.

Goldman Sachs has grown cautious on global equities in the near term, cutting its recommendation to neutral from overweight on a three-month basis. Read more on Goldman's bearish views.

/conga/story/misc/markets.html 240610

Most Asian markets were closed, eliminating one more possible driver for the market, said Dan Greenhaus, chief global strategist at BTIG.

While Monday may be lacking catalysts, retail sales data on Wednesday will likely have a big effect on stocks, according to a note from Citi?s Steven Englander.

With higher taxes kicking in on Jan. 1, ?retail sales will be the first really hard data on the impact of the tax hike,? Englander said. Read what's expected from retail sales.

Economists polled by MarketWatch forecast sales to show a scant 0.1% seasonally adjusted increase, reflecting the expiration of a payroll tax cut, higher gasoline prices, and delayed tax refunds.

The only other possible market catalyst in the next day or two is President Barack Obama?s annual State of the Union address Tuesday night. Read 'Obama to reward coalition in State of the Union speech.'

Shares of Google Inc. /quotes/zigman/93888/quotes/nls/goog GOOG -0.38% ?declined 0.4% after the Internet-search firm said late Friday that its chairman, Eric Schmidt, planned to sell nearly half of his stake in the company.

In the currency markets, the dollar /quotes/zigman/4867933/sampled EURUSD -0.0040% fell against the euro, but the U.S. dollar Index /quotes/zigman/1652083 DXY +0.18% ?, which measures the greenback against a basket of six other currencies, was trading at 80.35, compared with 80.25 late Friday. Read more on currencies.

News reports said officials from the Group of Seven nations continue to weigh the possibility of issuing a statement aimed at averting a so-called currency war. A pair of officials from the Group of 20 told Reuters that a G-7 statement could be released ahead of the meeting of G-20 finance ministers and central bankers in Moscow this week.

/quotes/zigman/627449

US : DJ-Index

Volume: 75.09M

Feb. 11, 2013 4:38p

/quotes/zigman/229488/quotes/nls/hd

US : U.S.: NYSE

Volume: 3.89M

Feb. 11, 2013 4:00p

Market Cap

$100.19 billion

Rev. per Employee

$219,100

/quotes/zigman/258846/quotes/nls/unh

US : U.S.: NYSE

Volume: 4.15M

Feb. 11, 2013 4:00p

/quotes/zigman/20493/quotes/nls/msft

US : U.S.: Nasdaq

Volume: 32.15M

Feb. 11, 2013 4:00p

Market Cap

$230.77 billion

Rev. per Employee

$774,085

/quotes/zigman/238207/quotes/nls/pfe

US : U.S.: NYSE

Volume: 26.12M

Feb. 11, 2013 4:00p

Market Cap

$197.91 billion

Rev. per Employee

$568,814

/quotes/zigman/3870025

US : S&P Base CME

Volume: 382.89M

Feb. 11, 2013 4:38p

/quotes/zigman/12633936

US : U.S.: Nasdaq

Volume: 0.00

Feb. 11, 2013 5:16p

/quotes/zigman/93888/quotes/nls/goog

US : U.S.: Nasdaq

Volume: 2.16M

Feb. 11, 2013 4:00p

Market Cap

$260.07 billion

Rev. per Employee

$927,536

/quotes/zigman/4867933/sampled

US : ICAP Currencies

Volume: 0.0000

Feb. 11, 2013 5:17p

/quotes/zigman/1652083

US : U.S.: ICE Futures U.S.

Volume: 0.00

Feb. 11, 2013 5:07p

Wallace Witkowski is a MarketWatch news editor in San Francisco. Follow him on Twitter @wmwitkowski. Polya Lesova is MarketWatch's New York deputy bureau chief. Follow her on Twitter @PolyaLesova.

Source: http://feeds.marketwatch.com/~r/marketwatch/internet/~3/AYJbJig-ytw/story.asp

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Sunday, February 10, 2013

Bieber screws up black history facts on 'SNL'

By Aaron Couch, The Hollywood Reporter

Dana Edelson / NBC

Justin Bieber hosted "Saturday Night Live" on Feb. 9.

Justin Bieber?seduced the audience and joked about smoking pot during this week?s?"Saturday Night Live."

During his opening monologue, the host and musical guest noted that February is home to both Valentine?s Day and Black History Month, so he would celebrate both. With help from?Kenan Thompson, the singer approached young women in the audience, presented them with a rose, and smooth talked them with some black history facts. He started off well ? but soon got his history mixed up.

Photos from THR: 12 'SNL' sketches made into movies

?Girl you?re driving me crazy, but did you also know?Denzel Washington?invented peanut butter?? he asked one young woman. Finally, surprise guest?Whoopi Goldberg?appeared and Bieber serenaded her with ?One Less Lonely Girl.?

Later, Bieber plays the ultimate?Miley Cyrus?(Vanessa Bayer) fan, appearing on her talk show and proclaiming his disdain for Justin Bieber. Bieber's character obliquely addresses photos that emerged in January of the singer smoking marijuana: ?I also heard he got busted smoking weed, and people make mistakes and he?s really sorry about it and he?s never going to do it again.?

"SNL"?kicked off the episode by revisiting Sunday?s Super Bowl blackout, which left the CBS Sports team with little to do but rehash old facts for thirty minutes. A more detailed description of what went down can be?read here, but sufficed to say, there?s awkward talk of?Dan Marino?s?(Jason Sudeikis) recently revealed extramarital affair and?Shannon Sharpe?s?(Jay Pharoah) desire to eat a punter.

Speaking of the Super Bowl, Thompson appeared on "Weekend Update"?as ?the one black guy in every commercial.? You know him ? the ?cool but non threatening? guy who is forever banging out a rhythm Pringles cans, DJing parties and high-fiving people ? all in the name of adding diversity to an ad campaign. Thompson?s character tells?Seth Meyers?his life is awesome, because he is constantly hanging out with ?Hispanic girls with bangs? and white guys who wear fedoras when they dance.

More from THR: 18 key stats from Justin Bieber's music empire

Bieber affected a greaser accent for a sketch derived from "Grease?s" ?Tell Me More? (renamed ?Say More Stuff? in "SNL"?parlance). Bieber?s character isn?t too smart, as it?s revealed he was disappointed on his date when he discovered ?sweater puppies? weren?t literally puppies hidden in a woman?s sweater.

The pop star nearly cracked up ala vintage?Jimmy Fallon?while playing a respectable pre-medical student who goes home to meet his girlfriend?s (Nasim Pedrad) family. Her oafish older brother (Taran Killam) screams in his face, just about causing Bieber to break.

Later, Bieber got to play a nerd who, along with his girlfriend (Pedrad), plan an abstinence-themed school dance.

"SNL"?is new next week with host?Christoph Waltz?and musical guest Alabama Shakes.

Which skit was your favorite? How did Bieber do? Share your thoughts on our Facebook page!

More in The Clicker:

Source: http://theclicker.today.com/_news/2013/02/10/16918125-justin-bieber-screws-up-black-history-on-saturday-night-live?lite

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Mass. boy dies of carbon monoxide in running car

(AP) ? An 11-year-old Massachusetts boy died of carbon monoxide poisoning Saturday after being overcome as he sat in a running car to keep warm, while his father was shoveling snow to get the car out of a snow bank.

Boston Fire Department spokesman Steve MacDonald said the boy was helping his father shovel the snow in the Dorchester neighborhood but got cold, so his father started the car and the boy got inside the vehicle. MacDonald said the car exhaust was covered by a snow bank, causing the fumes to collect in the car.

"I don't know how long the boy was in the car, at some point the father was still working and was unaware of the boy's condition," said Boston firefighter Octavius Rowe, who lives nearby and went to help. "So very, very unfortunate."

When the boy was overcome by the fumes, the father went into respiratory arrest and emergency workers took both to Boston Medical Center, officials said. The boy was pronounced dead at the hospital. No names were released.

Rowe said he was at home when he noticed a commotion in the street. He went outside and saw the father leaning against a pile of snow, Rowe said.

"I came over to the car where it all started and the father appeared to have lost consciousness," Rowe said. "He was semi-conscious and laying on the snow bank, and I wanted to first get him off that cold surface."

Rowe said he put the man on a flat surface to revive him. He said the boy apparently had been taken into an apartment building where a woman was administering CPR. Paramedics from the fire department and Emergency Medical Services arrived and provided oxygen to the father to stabilize him and tried to engage him in conversation to keep him alert.

"He was responsive so we were able to, at least, get him up, get him to the stairs. He did say, 'My son, my son,' so he knew his son was involved or was in distress," Rowe said. "We were talking to him. He was moaning, but the only discernible thing that he said was 'My son.'"

Rowe said his understanding was that a snow plow had come up the street and had pushed snow back onto the bank, which then impacted the car's exhaust pipe.

Also, fire officials said a man found in a car with the engine running in Mattapan on Saturday evening died of carbon monoxide poisoning, according to media reports. The Boston Globe said officials believe the car's tailpipe was blocked by snow, allowing the gas to build up.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-10-Northeast%20Storm-Boston%20Death/id-82a015f8ed1142b1ac9c17a55d59a0b7

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Monte Paschi expects state aid very soon

BERGAMO, Italy (Reuters) - Italy's troubled lender Monte dei Paschi expects to receive 3.9 billion euros ($5.2 billion) in state loans in a "very short time", Chairman Alessandro Profumo said on Saturday.

The funds, being provided through special bonds, are designed to shore up Italy's third largest bank, which has been at the centre of a financial and political storm over losses resulting from derivatives and structured finance trades.

"The bank will sign the 'Monti bond' in a very short time," said Profumo, talking with journalists on the sidelines of a business conference.

He gave no specific time frame and the European Commission still has to give its green light to the arrangement.

Monte Paschi Chief Executive Fabrizio Viola said the bank was currently not in talks with counterparts to restructure - "Santorini" and "Alexandria" - two of the derivatives trades at the heart of a fraud probe into the former management.

"We will evaluate what to do in the framework of the ordinary management of the bank," he said.

The bank said on Wednesday that losses linked to three problematic derivative trades, including "Santorini" and "Alexandria", totaled 730 million euros as it sought to draw a line under a scandal over risky financial transactions.

The executives confirmed the current business plan, but Viola said the European Commission could ask for changes as it considers whether to agree to the state loans.

(Reporting by Francesca Landini and Gianluca Semeraro; editing by Matthew Tostevin)

Source: http://news.yahoo.com/monte-paschi-sign-state-aid-very-short-time-092824595--finance.html

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Saturday, February 9, 2013

96% Monsters, Inc. 3D

All Critics (190) | Top Critics (41) | Fresh (194) | Rotten (8) | DVD (45)

This didn't need 3D to work. It long ago passed the kids-wear-out-the-DVD-rewatching-it test.

It may be harder nowadays to dazzle audiences with fancy visual effects, but Monsters, Inc. 3D proves that smart, imaginative storytelling still does the trick every time.

Most of the charm of "Monsters Inc." comes from its vocal cast.

If history is any guide, you and your family - whether young or old - will probably want to see "Monsters University" over and over.

The movie itself stands up well, even from an adult, two-dimensional perspective.

Its reassuring message is more relevant than ever.

While nippers will love the colourful creatures and their slapstick antics, grown-ups will find less humour and layers than in the likes of Toy Story, meaning less overall appeal as a result.

[I] really don't see the point of paying extra for children under eight. Their eyes are still developing, their noses are still small for slippery glasses, and... isn't a trip to the pictures enough for them in any case?

If anything, it improves with age.

Monsters displays wonderful imagination which makes it worth reliving in an extra dimension - particularly the energetic chase scene along a conveyor belt of doors.

Pixar's soaringly lovely fourth feature ...

[An] exciting, imaginative and very likable adventure.

Despite its eternal message about physical differences and the importance of love over fear of the unknown, Monsters, Inc primarily remains an ambitious concept film.

It's in the visuals that 'Monsters Inc' comes to life, from the jazzy, Norman McLaren influenced opening to the hilarious, shakycam amateur-dramatic recap over the closing credits.

Another chance to see Pixar's most dazzling premise, now spruced up with a third dimension.

Now in 3D, the filmmakers have created a wonderful reality - the reality of Monstropolis, which like the worlds of Oz and Pleasantville, whisk us far, far away on a magic carpet of fantasy

A shrewdly timed reminder of Pixar's early, heady days, when the animation powerhouse could do no wrong.

There's really little reason to check out Monsters, Inc. 3D in... well, 3D, rather than going for a good old-fashioned 2D screening instead.

It does well, but not brilliantly: an amusing trifle from a studio whose best work still lay ahead of it.

Not quite a Pixar classic, but funny, witty and visually spectacular enough to be enjoyed again on the big screen.

Monsters, Inc. continues a positive 3D trend for the company, who appear to be selecting their upgraded titles wisely, choosing features that benefit from the additional depth.

Not even the opportunistic 3D-ification can squander the pure delight of the film's meticulously detailed world of ragtag creatures.

Source: http://www.rottentomatoes.com/m/monsters_inc_3d/

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Map: Countries That Require Paid Sick Days

Have you joined millions of Americans this winter in the time-honored sport of projectile vomiting? Research suggests ill food-service workers cause most foodborne illness, but before you blame the guy who mixed your salad, try to keep this down: the United States is one of a handful of countries without federally mandated paid sick days for food service workers, and only a few cities and states require them. Without such laws, sick employees risk losing a day?s pay or even their jobs if they stay home and keep the rest of us healthy. But as support for such mandates swells once more, lawmakers are again mulling over the requirement, though businesses say they can?t stomach the potential costs.

Source: http://feeds.slate.com/click.phdo?i=37898e0900629a1e5e682d2901b3c70f

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Product Review: Redbox Instant by Verizon | Concert Katie

The latest product I?ve gotten to try from being a bzzagent is Redbox Instant from Verizon. ? Redbox Instant is kind of like 3 products in one. ?For $8 a month, you get an unlimited streaming subscription, 4 redbox kiosk codes and you also get the option of renting or buying movies from the site on your computer (for an added fee).

I?ve only used 2 of the 3 because I didn?t want to pay $5.99 for a movie rental. (The one movie I was interested in, I actually ended up getting at the red box kiosk with one of my free codes!)

As far as using the codes at the kiosk ? they are loaded on to your credit card. ?You pick your movie just like you would any other time you are using the kiosk. ?But when it is time to check out you click the button at the bottom that says ?Use Credits? and swipe your card. ?It lets you know that the credit went through and the first night is free. ?The only negative to this is that it can?t be used for BluRay. ?It would be nice if you could get the amount off of a regular DVD and just pay to upgrade to BluRay as an option because I?d much rather have rented a BluRay instead of a standard DVD. ?This was super easy and my favorite of the 3 features offered.

Streaming we were able to set up on our TV through our Samsung DVD Player. ?I believe at the moment that is the only brand that is allowing streaming as the Panasonic that I have in my bedroom doesn?t have it as an option. ?You can also stream through your computer or on select smartphones or tablets. ?(They are in the process of adding more devices though, so hopefully more will become available in the near future.)

The selection for movies to stream seem to be really old and I couldn?t find any TV shows (which is what I use some other streaming sites for) and I had a really hard time picking any movies to ?bookmark? to watch later. ?Going back to my bookmarks later I realized that I had only bookmarked ONE subscription streaming titles, the others were either for rent or at the kiosk. ?That movie was from when I was a kid ? Little Monsters with Howie Mandel and Fred Savage.

I think that the site needs to work a bit on its inventory and its site navigation because Ive talked to a few others and they have had similar complaints. ?I can?t say that I will be joining once my free trial runs out, though I would consider giving them another try in a year or so just to see if anything has changed.

I received a free 1 month trial via bzzagent in order to check out the site and write this review. I was not otherwise compensated. All opinions are my own.

Source: http://blog.concertkatie.com/2013/02/product-review-redbox-instant-by-verizon.html

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Friday, February 8, 2013

Chanticleer ? Returning to the Garden Four Weeks Later (Mid-June ...

2012/12/130bf_garden_office_7431360020_8bf4d2538d

Chanticleer ? Returning to the Garden Four Weeks Later (Mid-June)
garden office
Image by UGArdener
In mid May, we drove thirteen hours from Georgia up the Shenandoah Valley and across the Pennsylvania Turnpike to Wayne, PA, arriving at the gates of this great American Garden just before 6:00 PM to take advantage of the 8:00 Friday closing time.

(Here is the set of shots from the May visit: www.flickr.com/photos/ugardener/sets/72157629915442950/ )

In Mid-June, we returned on a Friday afternoon exactly four weeks later. These shots were taken quickly over the two hours just before the garden closed that afternoon. If you have time, you can run the SLIDESHOW of the new set in FullScreen Mode to follow us around the garden:

www.flickr.com/photos/ugardener/sets/72157630295266784/

Here is a link to the garden?s beautiful website, and a quote from it about its history:

www.chanticleergarden.org/

"The Chanticleer estate dates from the early 20th-century, when land along the Main Line of the Pennsylvania Railroad was developed for summer homes to escape the heat of Philadelphia. Adolph Rosengarten, Sr., and his wife Christine chose the Wayne-St. Davids area to build their country retreat. The family?s pharmaceutical firm would become part of Merck & Company in the 1920s.

The Rosengartens hired architect and former classmate Charles L. Borie to design the house, which was completed in 1913. Landscape architect Thomas Sears designed the terraces as extensions of the house. A 1924 addition converted the summer home into a year-round residence and the family moved here permanently.

Mr. Rosengarten?s humor is evident in naming his home after the estate "Chanticlere" in Thackeray?s 1855 novel The Newcomes. The fictional Chanticlere was "mortgaged up to the very castle windows" but "still the show of the county." Playing on the word, which is synonymous with "rooster," the Rosengartens used rooster motifs throughout the estate.

Adolph and Christine gave their two children homes as wedding presents. They purchased a neighboring property for son Adolph, Jr. and his bride Janet Newlin in 1933. It is now the site of the Ruin. Daughter Emily?s house, located at today?s visitor entrance, was built for her in 1935. It is presently used for offices and classrooms.

Adolph, Jr., bought his sister?s portion of the estate following her death in the 1980s. He didn?t move into the main house, but used it for entertaining and kept it as it was when the family lived there. The house is open for tours by reservation. Adolph, Jr., left the entire property for the enjoyment and education of the public following his death in 1990. A seven-member Board of Directors, five of whom are Rosengarten relatives, oversees The Chanticleer Foundation. The garden opened to the public in 1993. There are 17 full-time staff, of whom two manage facilities and 12 are gardeners and groundskeepers."

Here is an EXTENSIVE Plant List that shows the kind of horticultural craftsmanship and attention to detail that makes this garden and the staff who run it so special:

www.chanticleergarden.org/pdffiles/Chanticleer.pdf

..

Chanticleer ? Returning to the Garden Four Weeks Later (Mid-June)
garden office
Image by UGArdener
In mid May, we drove thirteen hours from Georgia up the Shenandoah Valley and across the Pennsylvania Turnpike to Wayne, PA, arriving at the gates of this great American Garden just before 6:00 PM to take advantage of the 8:00 Friday closing time.

(Here is the set of shots from the May visit: www.flickr.com/photos/ugardener/sets/72157629915442950/ )

In Mid-June, we returned on a Friday afternoon exactly four weeks later. These shots were taken quickly over the two hours just before the garden closed that afternoon. If you have time, you can run the SLIDESHOW of the new set in FullScreen Mode to follow us around the garden:

www.flickr.com/photos/ugardener/sets/72157630295266784/

Here is a link to the garden?s beautiful website, and a quote from it about its history:

www.chanticleergarden.org/

"The Chanticleer estate dates from the early 20th-century, when land along the Main Line of the Pennsylvania Railroad was developed for summer homes to escape the heat of Philadelphia. Adolph Rosengarten, Sr., and his wife Christine chose the Wayne-St. Davids area to build their country retreat. The family?s pharmaceutical firm would become part of Merck & Company in the 1920s.

The Rosengartens hired architect and former classmate Charles L. Borie to design the house, which was completed in 1913. Landscape architect Thomas Sears designed the terraces as extensions of the house. A 1924 addition converted the summer home into a year-round residence and the family moved here permanently.

Mr. Rosengarten?s humor is evident in naming his home after the estate "Chanticlere" in Thackeray?s 1855 novel The Newcomes. The fictional Chanticlere was "mortgaged up to the very castle windows" but "still the show of the county." Playing on the word, which is synonymous with "rooster," the Rosengartens used rooster motifs throughout the estate.

Adolph and Christine gave their two children homes as wedding presents. They purchased a neighboring property for son Adolph, Jr. and his bride Janet Newlin in 1933. It is now the site of the Ruin. Daughter Emily?s house, located at today?s visitor entrance, was built for her in 1935. It is presently used for offices and classrooms.

Adolph, Jr., bought his sister?s portion of the estate following her death in the 1980s. He didn?t move into the main house, but used it for entertaining and kept it as it was when the family lived there. The house is open for tours by reservation. Adolph, Jr., left the entire property for the enjoyment and education of the public following his death in 1990. A seven-member Board of Directors, five of whom are Rosengarten relatives, oversees The Chanticleer Foundation. The garden opened to the public in 1993. There are 17 full-time staff, of whom two manage facilities and 12 are gardeners and groundskeepers."

Here is an EXTENSIVE Plant List that shows the kind of horticultural craftsmanship and attention to detail that makes this garden and the staff who run it so special:

www.chanticleergarden.org/pdffiles/Chanticleer.pdf

..

Chanticleer ? Returning to the Garden Four Weeks Later (Mid-June)
garden office
Image by UGArdener
In mid May, we drove thirteen hours from Georgia up the Shenandoah Valley and across the Pennsylvania Turnpike to Wayne, PA, arriving at the gates of this great American Garden just before 6:00 PM to take advantage of the 8:00 Friday closing time.

(Here is the set of shots from the May visit: www.flickr.com/photos/ugardener/sets/72157629915442950/ )

In Mid-June, we returned on a Friday afternoon exactly four weeks later. These shots were taken quickly over the two hours just before the garden closed that afternoon. If you have time, you can run the SLIDESHOW of the new set in FullScreen Mode to follow us around the garden:

www.flickr.com/photos/ugardener/sets/72157630295266784/

Here is a link to the garden?s beautiful website, and a quote from it about its history:

www.chanticleergarden.org/

"The Chanticleer estate dates from the early 20th-century, when land along the Main Line of the Pennsylvania Railroad was developed for summer homes to escape the heat of Philadelphia. Adolph Rosengarten, Sr., and his wife Christine chose the Wayne-St. Davids area to build their country retreat. The family?s pharmaceutical firm would become part of Merck & Company in the 1920s.

The Rosengartens hired architect and former classmate Charles L. Borie to design the house, which was completed in 1913. Landscape architect Thomas Sears designed the terraces as extensions of the house. A 1924 addition converted the summer home into a year-round residence and the family moved here permanently.

Mr. Rosengarten?s humor is evident in naming his home after the estate "Chanticlere" in Thackeray?s 1855 novel The Newcomes. The fictional Chanticlere was "mortgaged up to the very castle windows" but "still the show of the county." Playing on the word, which is synonymous with "rooster," the Rosengartens used rooster motifs throughout the estate.

Adolph and Christine gave their two children homes as wedding presents. They purchased a neighboring property for son Adolph, Jr. and his bride Janet Newlin in 1933. It is now the site of the Ruin. Daughter Emily?s house, located at today?s visitor entrance, was built for her in 1935. It is presently used for offices and classrooms.

Adolph, Jr., bought his sister?s portion of the estate following her death in the 1980s. He didn?t move into the main house, but used it for entertaining and kept it as it was when the family lived there. The house is open for tours by reservation. Adolph, Jr., left the entire property for the enjoyment and education of the public following his death in 1990. A seven-member Board of Directors, five of whom are Rosengarten relatives, oversees The Chanticleer Foundation. The garden opened to the public in 1993. There are 17 full-time staff, of whom two manage facilities and 12 are gardeners and groundskeepers."

Here is an EXTENSIVE Plant List that shows the kind of horticultural craftsmanship and attention to detail that makes this garden and the staff who run it so special:

www.chanticleergarden.org/pdffiles/Chanticleer.pdf

..

Chanticleer ? Returning to the Garden Four Weeks Later (Mid-June)
garden office
Image by UGArdener
In mid May, we drove thirteen hours from Georgia up the Shenandoah Valley and across the Pennsylvania Turnpike to Wayne, PA, arriving at the gates of this great American Garden just before 6:00 PM to take advantage of the 8:00 Friday closing time.

(Here is the set of shots from the May visit: www.flickr.com/photos/ugardener/sets/72157629915442950/ )

In Mid-June, we returned on a Friday afternoon exactly four weeks later. These shots were taken quickly over the two hours just before the garden closed that afternoon. If you have time, you can run the SLIDESHOW of the new set in FullScreen Mode to follow us around the garden:

www.flickr.com/photos/ugardener/sets/72157630295266784/

Here is a link to the garden?s beautiful website, and a quote from it about its history:

www.chanticleergarden.org/

"The Chanticleer estate dates from the early 20th-century, when land along the Main Line of the Pennsylvania Railroad was developed for summer homes to escape the heat of Philadelphia. Adolph Rosengarten, Sr., and his wife Christine chose the Wayne-St. Davids area to build their country retreat. The family?s pharmaceutical firm would become part of Merck & Company in the 1920s.

The Rosengartens hired architect and former classmate Charles L. Borie to design the house, which was completed in 1913. Landscape architect Thomas Sears designed the terraces as extensions of the house. A 1924 addition converted the summer home into a year-round residence and the family moved here permanently.

Mr. Rosengarten?s humor is evident in naming his home after the estate "Chanticlere" in Thackeray?s 1855 novel The Newcomes. The fictional Chanticlere was "mortgaged up to the very castle windows" but "still the show of the county." Playing on the word, which is synonymous with "rooster," the Rosengartens used rooster motifs throughout the estate.

Adolph and Christine gave their two children homes as wedding presents. They purchased a neighboring property for son Adolph, Jr. and his bride Janet Newlin in 1933. It is now the site of the Ruin. Daughter Emily?s house, located at today?s visitor entrance, was built for her in 1935. It is presently used for offices and classrooms.

Adolph, Jr., bought his sister?s portion of the estate following her death in the 1980s. He didn?t move into the main house, but used it for entertaining and kept it as it was when the family lived there. The house is open for tours by reservation. Adolph, Jr., left the entire property for the enjoyment and education of the public following his death in 1990. A seven-member Board of Directors, five of whom are Rosengarten relatives, oversees The Chanticleer Foundation. The garden opened to the public in 1993. There are 17 full-time staff, of whom two manage facilities and 12 are gardeners and groundskeepers."

Here is an EXTENSIVE Plant List that shows the kind of horticultural craftsmanship and attention to detail that makes this garden and the staff who run it so special:

www.chanticleergarden.org/pdffiles/Chanticleer.pdf

..

Chanticleer ? Returning to the Garden Four Weeks Later (Mid-June)
garden office
Image by UGArdener
In mid May, we drove thirteen hours from Georgia up the Shenandoah Valley and across the Pennsylvania Turnpike to Wayne, PA, arriving at the gates of this great American Garden just before 6:00 PM to take advantage of the 8:00 Friday closing time.

(Here is the set of shots from the May visit: www.flickr.com/photos/ugardener/sets/72157629915442950/ )

In Mid-June, we returned on a Friday afternoon exactly four weeks later. These shots were taken quickly over the two hours just before the garden closed that afternoon. If you have time, you can run the SLIDESHOW of the new set in FullScreen Mode to follow us around the garden:

www.flickr.com/photos/ugardener/sets/72157630295266784/

Here is a link to the garden?s beautiful website, and a quote from it about its history:

www.chanticleergarden.org/

"The Chanticleer estate dates from the early 20th-century, when land along the Main Line of the Pennsylvania Railroad was developed for summer homes to escape the heat of Philadelphia. Adolph Rosengarten, Sr., and his wife Christine chose the Wayne-St. Davids area to build their country retreat. The family?s pharmaceutical firm would become part of Merck & Company in the 1920s.

The Rosengartens hired architect and former classmate Charles L. Borie to design the house, which was completed in 1913. Landscape architect Thomas Sears designed the terraces as extensions of the house. A 1924 addition converted the summer home into a year-round residence and the family moved here permanently.

Mr. Rosengarten?s humor is evident in naming his home after the estate "Chanticlere" in Thackeray?s 1855 novel The Newcomes. The fictional Chanticlere was "mortgaged up to the very castle windows" but "still the show of the county." Playing on the word, which is synonymous with "rooster," the Rosengartens used rooster motifs throughout the estate.

Adolph and Christine gave their two children homes as wedding presents. They purchased a neighboring property for son Adolph, Jr. and his bride Janet Newlin in 1933. It is now the site of the Ruin. Daughter Emily?s house, located at today?s visitor entrance, was built for her in 1935. It is presently used for offices and classrooms.

Adolph, Jr., bought his sister?s portion of the estate following her death in the 1980s. He didn?t move into the main house, but used it for entertaining and kept it as it was when the family lived there. The house is open for tours by reservation. Adolph, Jr., left the entire property for the enjoyment and education of the public following his death in 1990. A seven-member Board of Directors, five of whom are Rosengarten relatives, oversees The Chanticleer Foundation. The garden opened to the public in 1993. There are 17 full-time staff, of whom two manage facilities and 12 are gardeners and groundskeepers."

Here is an EXTENSIVE Plant List that shows the kind of horticultural craftsmanship and attention to detail that makes this garden and the staff who run it so special:

www.chanticleergarden.org/pdffiles/Chanticleer.pdf

..

08

Feb

Posted:

February 8, 2013 Friday at 1:56 pm

Source: http://syldrops.webhop.org/chanticleer-returning-to-the-garden-four-weeks-later-mid-june/

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Cells forged from human skin show promise in treating multiple sclerosis, myelin disorders

Feb. 7, 2013 ? A study out February 7 in the journal Cell Stem Cell shows that human brain cells created by reprogramming skin cells are highly effective in treating myelin disorders, a family of diseases that includes multiple sclerosis and rare childhood disorders called pediatric leukodystrophies.

The study is the first successful attempt to employ human induced pluripotent stem cells (hiPSC) to produce a population of cells that are critical to neural signaling in the brain. In this instance, the researchers utilized cells crafted from human skin and transplanted them into animal models of myelin disease.

"This study strongly supports the utility of hiPSCs as a feasible and effective source of cells to treat myelin disorders," said University of Rochester Medical Center (URMC) neurologist Steven Goldman, M.D., Ph.D., lead author of the study. "In fact, it appears that cells derived from this source are at least as effective as those created using embryonic or tissue-specific stem cells."

The discovery opens the door to potential new treatments using hiPSC-derived cells for a range of neurological diseases characterized by the loss of a specific cell population in the central nervous system called myelin. Like the insulation found on electrical wires, myelin is a fatty tissue that ensheathes the connections between nerve cells and ensures the crisp transmission of signals from one cell to another. When myelin tissue is damaged, communication between cells can be disrupted or even lost.

The most common myelin disorder is multiple sclerosis, a condition in which the body's own immune system attacks and destroys myelin. The loss of myelin is also the hallmark of a family of serious and often fatal diseases known as pediatric leukodystrophies. While individually very rare, collectively several thousand children are born in the U.S. with some form of leukodystrophy every year.

The source of the myelin cells in the brain and spinal cord is cell type called the oligodendrocyte. Oligodendrocytes are, in turn, the offspring of another cell called the oligodendrocyte progenitor cell, or OPC. Myelin disorders have long been considered a potential target for cell-based therapies. Scientists have theorized that if healthy OPCs could be successfully transplanted into the diseased or injured brain, then these cells might be able to produce new oligodendrocytes capable of restoring lost myelin, thereby reversing the damage caused by these diseases.

However, several obstacles have thwarted scientists. One of the key challenges is that OPCs are a mature cell in the central nervous system and appear late in development.

"Compared to neurons, which are among the first cells formed in human development, there are more stages and many more steps required to create glial cells such as OPCs," said Goldman. "This process requires that we understand the basic biology and the normal development of these cells and then reproduce this precise sequence in the lab."

Another challenge has been identifying the ideal source of these cells. Much of the research in the field has focused on cells derived from tissue-specific and embryonic stem cells. While research using these cells has yielded critical insight into the biology of stem cells, these sources are not considered ideal to meet demand once stem cell-based therapies become more common.

The discovery in 2007 that human skin cells could be "reprogrammed" to the point where they returned to a biological state equivalent of an embryonic stem cell, called induced pluripotent stem cells, represented a new path forward for scientists. Because these cells -- created by using the recipient's own skin -- would be a genetic match, the likelihood of rejection upon transplantation is significantly diminished. These cells also promised an abundant source of material from which to fashion the cells necessary for therapies.

Goldman's team was the first to successfully master the complex process of using hiPSCs to create OPCs. This process proved time consuming. It took Goldman's lab four years to establish the exact chemical signaling required to reprogram, produce, and ultimately purify OPCs in sufficient quantities for transplantation and each preparation required almost six months to go from skin cell to a transplantable population of myelin-producing cells.

Once they succeeded in identifying and purifying OPCs from hiPSCs, they then assessed the ability of the cells to make new myelin when transplanted into mice with a hereditary leukodystrophy that rendered them genetically incapable of producing myelin.

They found that the OPCs spread throughout the brain and began to produce myelin. They observed that hiPSC-derived cells did this even more quickly, efficiently, and effectively than cells created using tissue-derived OPCs. The animals were also free of any tumors, a dangerous potential side effect of some stem cell therapies, and survived significantly longer than untreated mice.

"The new population of OPCs and oligodendrocytes was dense, abundant, and complete," said Goldman. "In fact, the re-myelination process appeared more rapid and efficient than with other cell sources."

The next stage in evaluating these cells -- clinical studies -- may not be long in the offing. Goldman, along with a team of researchers and clinicians from Rochester, Syracuse, and Buffalo, are preparing to launch a clinical trial using OPCs to treat multiple sclerosis. This group, titled the Upstate MS Consortium, has been approved for funding by New York State Stem Cell Science (NYSTEM). While the consortia's initial study -- the early stages of which are scheduled to begin in 2015 -- will focus cells derived from tissue sources, Goldman anticipates that hiPSC-derived OPCs will eventually be included in this project.

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Story Source:

The above story is reprinted from materials provided by University of Rochester Medical Center, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Su Wang, Janna Bates, Xiaojie Li, Steven Schanz, Devin Chandler-Militello, Corri Levine, Nimet Maherali, Lorenz Studer, Konrad Hochedlinger, Martha Windrem, Steven?A. Goldman. Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination. Cell Stem Cell, 2013; 12 (2): 252 DOI: 10.1016/j.stem.2012.12.002

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/GKe-m1957SA/130207131606.htm

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Google to crowdsource Indian mapping data, offers swag to top contributors

Google to crowdsource Indian mapping data in exchange for swag

What's the best method of finding your way in a foreign land? Just ask the locals, and that's exactly what El Goog is doing in India with its Mapathon 2013 competition. The contest is running from February 12th through March 25th, and is asking residents of the Asian nation to add additional detail or update information in Google Maps using Map Maker. Working for Google without actually working for Google isn't very alluring, so to compensate participants for their knowledge and effort, the search giant is offering prizes -- slates, phones, vouchers (presumably for the Play store) and other merchandise -- for the top 1,000 contributors. If you're willing and able to get involved, head to the source link for the lowdown on how. When you finally get round to seeing the Taj Mahal in person and check your phone for the nearest watering hole, remember to raise a toast to Mapathon 2013 for getting you there.

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Comments

Source: Google India Blog

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/J5w3sLr7IBk/

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Lungs of the planet reveal their true sensitivity to global warming

Thursday, February 7, 2013

Tropical rainforests are often called the "lungs of the planet" because they generally draw in carbon dioxide and breathe out oxygen. But the amount of carbon dioxide that rainforests absorb, or produce, varies hugely with year-to-year variations in the climate. In a paper published online this week (Feb 6 2013) by the journal Nature, a team of climate scientists from the University of Exeter, the Met Office-Hadley Centre and the NERC Centre for Ecology & Hydrology, has shown that these variations reveal how vulnerable the rainforest is to climate change.

Lead author Professor Peter Cox of the University of Exeter explained: "We have been struggling for more than a decade to answer the question 'will the Amazon forest die back under climate change?' Our study indicates that the risk is low if climate change is associated with increased plant growth under elevated carbon dioxide. But if this effect declines, or climate warming occurs due to something other than a carbon dioxide increase, we expect to see a significant release of carbon from tropical ecosystems".

The study reveals a new way to find out how sensitive biological systems are to changes in climate. The key was to learn how to read the year-to-year variations in the concentration of carbon dioxide in the atmosphere. Carbon dioxide increases each year as a result of burning fossil fuels and deforestation. But the amount it goes up from one year to the next depends on whether tropical forests are absorbing carbon dioxide or releasing it ? and this in turn depends on whether the tropical climate was warmer and dryer than usual, or wetter and cooler. So the trace of carbon dioxide in the atmosphere holds a record of how the lungs of the planet respond when the climate warms or cools.

The team studied how these year-to-year variations in carbon dioxide concentration relate to long-term changes in the amount of carbon stored in tropical rainforests. They found that climate models that predicted tropical forest dieback under climate change also had a very large year-to-year variation in carbon dioxide concentration, while models in which the rainforest was more robust to climate change had more realistic year-to-year variation in carbon dioxide concentration.

By combining this relationship with the year-to-year variation in carbon dioxide as seen in the real world, the team were able to determine that about 50 billion tonnes of carbon would be released for each degree Celsius of warming in the tropics. Peter Cox said the findings were initially a relief: "Fortunately, this carbon release is counteracted by the positive effects of carbon dioxide fertilisation on plant growth under most scenarios of the 21st century, so that overall forests are expected to continue to accumulate carbon."

The researchers are however certain that tropical forests will suffer under climate change if carbon dioxide doesn't fertilise tree growth as strongly as climate models suggest.

Co-author, Chris Jones, of the Met Office said: "The long-term health of tropical forests will depend on their ability to withstand multiple pressures from changing climate and deforestation. Our research has shed light on the former, but the latter remains a significant pressure on this ecosystem."

###

University of Exeter: http://www.exeter.ac.uk

Thanks to University of Exeter for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126675/Lungs_of_the_planet_reveal_their_true_sensitivity_to_global_warming

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Thursday, February 7, 2013

Oksana Baiul Sues NBC For $5 Million

Source: http://www.thehollywoodgossip.com/2013/02/oksana-baiul-sues-nbc-for-5-dollars-million/

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Whatever happened to Eastwood's RNC chair?

By Randee Dawn, TODAY contributor

One of the most indelible images from 2012's Republican National Convention came during Clint Eastwood's speech, where he decided to address a chair as if it was President Obama. It became an immediate source of ridicule to some, and inspirational improv to others. But where do famous chairs go after taking their seat in the spotlight?

In this case, it turns out to the office of Reince Priebus, chairman of the Republican National?Committee. He told NBC's Luke Russert that he knew he had to have the chair "two minutes" after the speech began.

"I told my wife and a couple of folks that were around me, 'Let's get that chair,'" he said.

Priebus says he keeps the chair around to remind himself what will resonate with the public, after an extended period when his party is considered to be out of touch with many Americans.

"We have to accept where our culture's at and be a part of it, and still espouse the good principles of our party, but maybe make a change in that area," he said.

Now, six months after the convention, Priebus says the chair is the most popular item in his office, and visitors always ask to have a photo taken with the item.

You could say it's making a chair-table contribution.

Related content:

More in TODAY Entertainment:

Source: http://todayentertainment.today.com/_news/2013/02/06/16868209-clint-eastwoods-rnc-chair-gets-a-second-life-in-washington-dc?lite

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BlackBerry Z10 is selling even better than BlackBerry expected so far

BlackBerry Z10 SalesBlackBerry Z10

BlackBerry (BBRY) shares were up sharply on Monday as analysts continued to upgrade the stock. The reinvigorated vendor also got some potentially game-changing news recently as one plugged-in industry watcher reported that half of early BlackBerry Z10 demand in Canada was coming from people who aren?t currently BlackBerry users. But will all this good news translate into solid sales? We likely won?t know any firm numbers for quite some time but according to BlackBerry, Z10 sales to date have been even better than the company expected.

[More from BGR: Google?s big potential problem: The ?Galaxy? brand is starting to beat the ?Android? brand]

BlackBerry?s first crack at a full-touch BlackBerry 10 smartphone launched last week in the UK and according to BlackBerry UK managing director?Stephen Bates, sales have been strong so far.

[More from BGR: iOS 6.1 untethered jailbreak now available for download, compatible with iPhone 5 and iPad mini]

?The response we?ve seen exceeded all of our launch partners? expectations. Customers are choosing to buy the BlackBerry Z10 in large numbers,? Bates told TechCrunch. ?In fact some of our partners have told us that they sold out over the weekend in some of their key retail locations.?The partners? call centres are also flooded with calls, as people phone to ask for more information about the device, and also where and how to buy it.?

The BlackBerry Z10 launches in Canada and some European markets on Tuesday, February 5th, and it will be released in the United States starting in mid-March.

This article was originally published on BGR.com

Source: http://news.yahoo.com/blackberry-z10-selling-even-better-blackberry-expected-far-150551827.html

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